In a bowl, add warm water and yeast. Wait about 5 minutes to allow the yeast to "proof". Stir after the 5 minutes to make sure yeast is completely dissolved.
In another bowl, add flour, onion powder, garlic powder, sugar, oregano and Parmesan cheese. Mix well, then add olive oil and mix again.
Combine both bowls into one and start kneading the mixture to create a dough consistency. Add more flour if necessary. Keep kneading until the dough is no longer sticky and feels soft to the touch. Roll the dough into a ball form.
In a bowl, coat with oil and place ball of dough into bowl, rolling it around for a light coat. Put bowl aside for 2 to 3 hours to allow dough to rise.
Once dough has risen (should be about double it's size), place on a lightly floured surface and use rolling pin to roll into a round shape for your pizza.
Create a lip around the edge of your dough, about 1½ inches in from the edge. Fill in lip with Mozzarella cheese, fold dough over and create a seal.
Evenly spread desired amount of pizza sauce, remaining Mozzarella cheese and top with pepperonis.
Bake at 475 for 11-12 minutes. Pizza will be done with dough is golden and cheese on top is completely melted.
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